Co-Polymer Coated Controlled Pore Glass Solid Support
Applied to medium to extra-long chain oligonucleotide synthesis
Key Advantages of Our Co-Polymer Coated CPG
High Loading Capacity
Our co-polymer coated CPG solid support features a loading capacity that is 2–3 times higher than traditional CPG (e.g., 160 μmol/g for 500 Å; 80 μmol/g for 2000 Å).
Corrosion Resistance
Inert to chemical reagents and solvents during the synthesis and the subsequent treatments
Non-Swelling
preventing resin expansion during chemical reactions
Long-Chain Synthesis
Efficient synthesis from hundreds up to thousands of bases
- siRNA / ASO Drugs
- Fluorescent Labeling
- Quencher Modification
- Biotin Tagging
- Electrochemical Detection
- High-Throughput Screening
- Harsh-Condition Stability
- Structural Modifications
- GalNAc Delivery Systems
- Cholesterol Delivery Systems
- Personalized Therapeutics
Applications of Our Co-polymer Coated CPG for All Types of Oligonucleotides
Our Co-Polymer Coated CPG solid supports are suitable for siRNA and ASO production. Our remarkable purity and great loading capacity propel the development of contemporary nucleic acid therapies.
Patented Hybrid: Polystyrene + CPG
By using our unique technology, we successfully apply polystyrene resin onto the surface of traditional controlled pore glass CPG without significantly altering the original pore size of CPG and create a high loading, high purity co-polymer coated controlled pore glass solid support.This new patented technology helps us overcome the difficulties involved in the large-scale manufacturing of oligonucleotide therapeutics.
Optimal solid support for direct cell delivery
As the most suitable solid support for direct integration with delivery systems such as GalNAc or cholesterol, it enables incorporation at the early stages of oligonucleotide synthesis. This significantly reduces downstream purification costs and streamlines the entire process from synthesis to final drug product.
Step 1: Define Requirements
Specify the oligonucleotide type, desired co-polymer coated CPG pore size, linker, and chemical modifications.
Step 2: Technical Review & Quote
Our technical team assesses your needs, offers a quote, and resolves technical concerns through online meetings or emails.
Step 3: Sample Production
We produce small-batch samples for testing, allowing comparison with conventional CPG to assess performance advantages.
Step 4: Confirm & Adjust Process
The customer arranges for a modification in the manufacturing process to switch from traditional CPG to our co-polymer coated CPG after our hybrid support performance has been verified.
Step 5: Bulk Production & Delivery
We manufacture the required quantity of hybrid solid support according to your synthesis scale and deliver it to your site.
High Loading Capacity for Long-Chain Oligonucleotide Synthesis
Our co-polymer-coated controlled pore glass solid support, perfectly combined with polystyrene resin, offers 2–3 times higher loading than conventional CPG, enabling more efficient oligonucleotide synthesis and reducing equipment and facility requirements for CDMOs, CMOs, and CROs.
+160
μmol/g (500 Å)
+100
μmol/g (1000 Å)
+80
μmol/g (2000 Å)
Our Co-Polymer Coated Controlled Pore Glass (CPG) Product Line
We offer co-polymer coated controlled pore glass supporting a wide range of chemical modifications, widely applied in ASO, siRNA, and other oligonucleotide synthesis applications.
DNA Modified CPG (Co-Polymer)
Modification Capability: dA, dC (Ac), dC (Bz), dG (iBu), dG (dmf), dT
RNA Modified CPG (Co-Polymer)
Modification Capability: rA (Bz), rC (Ac), rC (Bz), rG (iBu), rG (dmf), rU, 2'OAc, tA(Ac), 2'OAc
2'-O-Methyl Modified CPG (Co-Polymer)
Modification Capability: 2'OMe rA (Bz), 2'OMe rC (Ac), 2'OMe rC (Bz), 2'OMe rG (iBu), 2'OMe rG (dmf), 2'OMe rU
Reverse CPG (Co-Polymer)
Modification Capability:3'DMT dT, 3'DMT dA (Bz), 3'DMT dC (Bz)
LNA Modified CPG (Co-Polymer)
Modification Capability:LNA A (Bz), LNA C (Bz), LNA G (dmf), LNA T
2'-F Modified CPG (Co-Polymer)
Modification Capability:2'F A (Bz), 2'F C (Ac), 2'F G (iBu), 2'F U
Easy Compliance with Authorities
FDA/EMA
GMP
Our Co-Polymer Coated Controlled Pore Glass for Functional Oligonucleotides
Latest Articles
Learn more about solid support technology and the significance of our next-generation co-polymer coated CPG in enabling the development of long-chain oligonucleotide medicines for the future.
Co-Polymer Coated CPG vs. Traditional CPG: Breaking the Technical Ceiling of Large-Scale Long-Mer Nucleic Acid Synthesis
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Understanding Loading Capacity in Controlled Pore Glass (CPG)
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Complete guide of sirna and aso technology
Explore the evolution of oligonucleotide therapeutics, from foundational chemical synthesis to advanced ASO technology and siRNA modalities. This comprehensive review analyzes RNase H-mediated degradation and RNAi mechanisms, highlighting the transformative role of GalNAc and LNP delivery systems in overcoming metabolic stability barriers for rare and metabolic disease treatment.
More Questions You May Have
What is the pore size range of your hybrid solid support?
We offer standard pore sizes of 500 Å, 1000 Å, 2000 Å, and 3000 Å for general applications.
Do you offer custom pore sizes for customer applications?
Yes, we can provide custom pore sizes tailored to specific customer requirements.
Can your co-polymer coated CPG be integrated with a cell delivery system?
Yes, our hybrid support allows direct installation of cell delivery systems, such as GalNAc, cholesterol, and others.
What about the oligonucleotide purity that was produced with your hybrid CPG support?
Because our hybrid CPG support is inert to chemical reagents and solvents during synthesis, it allows for better purity than regular CPG.
What is the typical production lead time for your co-polymer coated CPG products?
Depending on the particular needs and customizations of the customer, production usually takes four to five weeks.
Is your hybrid CPG support product pre-activated?
Yes, our product is ready to use and fully active; no more processing is needed.
Does the resin coating on your CPG pose a risk of swelling during chemical reaction?
No, The CPG’s solid physical structure and ultra-thin resin coating assist ensure that it won’t swell throughout the reaction.
Do you offer CPG column products?
Yes, we provide CPG column with our co-polymer coated CPG solid support, suitable for research and laboratory applications.
Do your products support industrial-scale oligonucleotide synthesis?
Yes, our products are designed for industrial-scale, large-quantity oligonucleotide synthesis, typically for molecule amounts at the mmol scale or above.
What types of oligonucleotide therapeutics are your products mainly used for?
Our co-polymer coated CPG is primarily applied to ASO, siRNA,etc.
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