1. Introduction This experiment was designed to evaluate the performance of our 1000 Å Co-Polymer Coated CPG in the practical synthesis of medium-length oligonucleotides, with a specific focus on RNA synthesis. Notably, this evaluation was conducted under our high-loading condition of 105 µmol/g, whereas traditional modified CPG of the same pore size typically exhibits a […]
Introduction 120 nt RNA is considered a long-chain RNA product, and the development of RNA therapeutics is driving increasing demand for longer and more highly modified RNA sequences. Long-chain RNA synthesis becomes increasingly challenging when bulky protecting groups such as TBDMS are introduced. The steric demand of TBDMS chemistry can negatively affect coupling efficiency and
Introduction Synthesizing long RNA strands—especially complex sequences exceeding 100 nucleotides (nt) with extensive 2′-OMe modifications—has long been one of the most challenging bottlenecks in oligonucleotide manufacturing with traditional functionalized controlled pore glass (CPG). Low stepwise coupling efficiency, steric hindrance from chemical modifications, and the accumulation of truncation impurities (n-1, n-2 failure sequences) typically result in
Driven by the explosive growth of nucleic acid therapies such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and CRISPR gRNA genome editing, the global biopharmaceutical industry’s demand for large-scale, high-purity raw materials has reached unprecedented heights. However, a major “bottleneck” restricting capacity and escalating costs lies in a core step of manufacturing these advanced
Certificate of Analysis (COA) Product Information Item Details Product Name Co-Polymer Coated CPG 2000Å+ 2′-OMe-rU Lot# 86025-02036A Mfg Date 5/19/2026 Report Date 5/20/2026 Quality Control Results Items Specification QC Data Results Pore Size 2000Å ± 200 2015Å Pass Particle Size 120–180 Mesh 120–180 Mesh Pass Bulk Density 0.22–0.3 g/cm³ 0.25 g/cm³ Pass Surface Area 25–40
Certificate of Analysis (COA) Product Information Item Details Product Name Co-Polymer Coated CPG 1000Å+ 2′-OMe-rU Lot# 86025-02030A Mfg Date 4/1/2026 Report Date 4/3/2026 Quality Control Results Items Specification QC Data Results Pore Size 1000Å ± 200 1015Å Pass Particle Size 120–180 Mesh 120–180 Mesh Pass Bulk Density 0.22–0.3 g/cm³ 0.23 g/cm³ Pass Surface Area 25–40
We are excited to announce that PoresynSolutions(also called Poresyn Technologies) will be exhibiting at TIDES US 2026, held in Boston this year. You can find us at booth #1102. As a leader in the field of oligonucleotide synthesis, we warmly invite industry professionals to visit us and explore the latest advancements and collaboration opportunities. At
Certificate of Analysis (COA) Product Identification Technical Specifications & Quality Control Results Test Items Specification Standard QC Testing Data Test Results Pore Size 2000Å ± 200 2015 Å Pass Particle Size 120-180 Mesh 120-180 Mesh Pass Bulk Density 0.22 – 0.3 g/cm³ 0.25 g/cm³ Pass Surface Area 25 – 40 m²/g 33.19 m²/g Pass Nucleoside
Certificate of Analysis Product Information Specifications and Results Items Specification QC Data Results Pore Size 1000ű200 1015 Å Pass Particle Size 120-180 Mesh 120-180 Mesh Pass Bulk Density 0.22-0.3g/cm³ 0.23g/cm³ Pass Surface Area 25-40m²/g 33.19m²/g Pass Nucleoside Loading > 80µmol/g 92 µmol/g Pass Appearance Off-white solid Off-white solid Pass Technical Summary This Certificate of Analysis
