Galnac CPG(Co-Polymer) Solid Support
Being as the most suitable platform of solid support to install cell delivery like GALNAC.
Easier GalNAc installation: The unique architecture of PS combining with CPG make our solid support more easily to install cell delivery.
Enhanced GalNAc performance: Better effect of conjugation with GALNAC with better cell delivery outcomes.
Co-polymer coated CPG with GalNac
Pre-installed GalNAc
Prior to oligonucleotide synthesis, Galnac is preloaded on our co-polymer coated CPG solid support, which helps streamline the API drug production process and reduce further downstream purifying expenses.
Increased Effectiveness of Cell Delivery
The α-anomeric dR-GalNAc linkage enhances the targeted delivery efficacy of siRNA, ASO, saRNA, and anti-miRNA therapies by having a higher affinity for hepatocyte ASGPR receptors.
Stable and resistant to nucleases
While the α-GalNAc structure enhances stability and anti-nuclease performance, oligo integrity could be confirmed both in biosystems and during synthesis.
Organic Harmony with Oligo
Because dR functions similarly to natural sugar-phosphate, it can provide smooth oligonucleotide integration and hence improve drug delivery to cells.
Main Advantages of our co-polymer coated CPG solid support
Super High Loading Capacity
Our co-polymer coated CPG solid support has a loading capacity that is approximately 3-6 times higher than traditional CPG. Under the same conditions, switching to our super solid support can increase output by 300–60%
Long-Chain Oligo Synthesis Capability
The co-polymer coated CPG from Poresynsolutions facilitates the synthesis of oligos with lengths ranging from 20 to 300 nt while also maintaining high loading. In general, our super solid foundation can meet the various length requirements of nowadays oligonucleotide medications, even those that are more than 300 nt long.
High Reactive Surface
With the help of our reactive resin surface, our super solid support can guarantee the oligo synthesis process proceeds smoothly without the need to add additional molecular group like LCAA.
High Purity Output
Compared with traditional CPG, poresynsolutions’ co-polymer coated solid support delivers significantly higher oligonucleotide purity. UV test results show >80% purity in general, whereas traditional CPG typically reaches only ~60%.
Resistance to Reagents and Solvents
Poresynsolutions’ new patented solid support is inert to chemical reagents or solvents and subsequent treatments, we can significantly improve the purity of the oligo synthesis result in this way.
GMP Safety Guarantee
The polystyrene coating surface of our super solid support is quite thin, and it is protected by the stable CPG architecture, which prevents it from swelling throughout the synthesis process. Furthermore, in contrast to conventional CPG, our solid support won't generate CPG fragments, reducing the possibility of a blocked synthetic instrument pipeline and, consequently, high back pressure problems. In this approach, we ensure a safe environment for the manufacture of GMP-Scale oligonucleotides.
Oligonucleotide Solid Support Specifications
| Parameter | Specification |
|---|---|
| Oligonucleotide Length | 20–300 nt |
| Pore Size & Loading | 500 Å – ~240 μmol/g (Unylinker loading) 1000 Å – ~200 μmol/g (Unylinker loading) 2000 Å – ~160 μmol/g (Unylinker loading) |
| UV Purity | Generally ≥ 80% |
Poresynsolutions’ super solid support can synthesize oligos with lengths ranging from 20 to 300 nt. Its loading capacity varies between 160 and 240 μmol/g, depending on the size of its pores. Using our solid support usually results in UV purity levels of over 80%.
- DNA Modified CPG (Co-Polymer)
- RNA Modified CPG (Co-Polymer)
- 2′-O-Methyl Modified CPG (Co-polymer)
- Reverse CPG (Co-Polymer)
- 2′-F Modified CPG (Co-Polymer)
- LNA Modified CPG (Co-Polymer)
Our Standard CPG(Co-Polymer) Pore Size Range
Our product line, which spans from 500Å to 3000Å, can accommodate the majority of oligo medicines available today. We can also provide bespoke pore sizes larger than 3000A for research purposes.
The Importance of Cell Delivery Systems
Oligotherapies have demonstrated great potential in treating a wide range of challenging diseases. Effectively delivering API medications to the targeted cell is challenging though, because their large molecular groups and negative charges make it difficult for them to penetrate through the cell membrane. For this reason, a cell delivery mechanism that is both protective and efficient is essential.
GalNAc-Mediated Liver Targeting
Currently, the most frequently utilized method for cell delivery is to target the liver by using the asialoglycoprotein receptor (ASGPR). On the surface of hepatocytes (liver cells), this receptor is quite widespread and expresses itself uniquely. The molecule is successfully changed into the desired home position for the liver by connecting the Galnac cluster to the oligonucleotide. The complex is quickly drawn into the cell via receptor-mediated endocytosis once the GalNAc-modified oligonucleotide binds to ASGPR. Following internalization into endosomes, the oligonucleotide’s GalNAc component is finally broken down, releasing it into the cytoplasm where it can attach to its target mRNA and carry out its therapeutic activity, including RNA interference (RNAi).
Related Products
Co-Polymer Coated CPG with Unylinker
This universal linker solution makes small-scale biopharmaceutical research and testing more easier. Direct incorporation of the desired nucleic acid monomer onto the solid support is made simple by this modified solid support.
Co-Polymer Coated CPG with Cholesterol
We also provide the co-polymer coated CPG solid support linked with cholesterol delivery system. Our super solid support, in contrast to traditional CPG solid support, makes it simpler to install the cholesterol while yet providing superior functional performance.