Poresyn Solutions - Modified DNA Co-Polymer Coated CPG
Poresyn Solutions’ DNA Modified CPG co-polymer offer:
3-6x loading capacity than conventional CPG and high purity performance to lown down your cost of goods(COG).
Small MOQ
We support small MOQs, starting from 10 g, for the Universe linker type.
Tailored Solutions
No matter what kind of linker you need, we can fulfill unique requests.
Free Sample For Test
Providing small sample of our HL-CPG with Unylinker for testing without charge
Free Delivery
Free air shipping, typically, the things arrive within seven days.
DNA Modified CPG (Co-Polymer)
Main Advantages of our HL-CPG
- High load capacity: 3-6x loading capacity than traditional CPG solid support.
- Anti-corrosion: iner to chemical reagents and solvents during synthesis and subsequents treatments.
- Non-swelling properties: preventing the swelling of resin during chemical reaction.
- Long-chain bases synthesis: supporting medium to extra long chain bases synthesis.
- No silica contamination: During ammonolysis, no silica contamination is produced because of the special PS–CPG cross-linked architecture.
Engineered for Long-Chain Oligonucleotide Synthesis
Our new architecture co-polymer coated cpg is designed for oligonucleotide synthesis, especially for ASO or SIRNA, this hybrid CPG solid support inherit the long-chain synthesis capability for oligonucleotide that it enables us to efficiently synthesis bases length ranging from tens to hundreds to even thousands.
Outstanding Loading Capacity
This thin layer of PS makes it easy to increase the load capacity of our hybird solid support, doubling it without compromising the ability to synthesize long-chain bases. This is made possible by the high load characteristics of polystyrene.
What is HL-CPG
HL-CPG
Our DNA Modified Co-Polymer Coated CPG Solid Support
Following are the principal monomer types linked to our co-polymer coated CPG solid support for DNA synthesis.
OUR PRODUCT
Superior Advantages of our HL-CPG (Co-Polymer Coated CPG Solid Support)
By utilizing our HL-CPG, users typically achieve a 30–70% reduction in cost of goods (COG) compared with conventional functionalized CPG, thanks to its high loading capacity, superior purity, and overall process efficiency
High Loading
3–6× higher loading than traditional CPG supports — e.g., our 2000Å HL-CPG achieves 160 μmol/g
High Purity
Delivers >80% oligo purity, owing to strong chemical resistance to reagents and solvents
No Swelling
Unlike traditional polystyrene supports, our HL-CPG remains stable and does not swell under reaction or heating conditions, ensuring consistent synthesis performance
High surface reactivity
The ps layer provides high surface reactivity, resulting in outstanding synthesis performance even when no LCAA is coupled.
No Silica Contamination
No glass particles are generated during ammonolysis, thanks to the PS surface crosslinked with the CPG core structure, ensuring cleaner synthesis and easier purification.
Fully Compatible Setup
Fully compatible with existing CPG-based synthesis setups — no equipment modification required
DNA Modified CPG Co-Polymer
Higher oligonucleotide product output purity
The polystyrene-coated CPG makes our solid support resistant to chemical reagents and solvents that would normally melt impurities like glass particles into the nucleotide molecule, improving the quality of the oligo products and significantly lowering the downstream purity cost.
loading capacity of our hl-cpg
Comparision with Traditional CPG Solid Support
Stop settling for trade-offs! Unlike traditional CPG, Poresyn Solutions’ hybird co-polymer coated CPG solid support multiplies your manufacturing potential: you get 3x to 6x greater load capacity plus a major increase in purity. This powerful synergy means you can expect your production line to yield over more output. Scale faster and cheaper—without compromising quality.
| CPG Pore Size (Å) | Applicable Oligonucleotide Synthesis Length (nt) | Traditional CPG Typical Load (µmol/g) | Poresyn Solutions Advantage Load (µmol/g) | Load Capacity Improvement |
|---|---|---|---|---|
| 500 Å | <40mer | 30-50 (Standard) | ~240 | 5X - 8X |
| 1000 Å | 40-100mer | 20-40 | ~160 | 2.5X - 6X |
| 2000 Å | 100-300mer | 10-30 | ~100 | 3X - 10X |
What is DNA Modified CPG?
() serves as the starting solid support for oligonucleotide synthesis. It refers to a CPG bead that has been chemically linked with a deoxyribonucleotide single unit (). This attached unit acts as the terminus (starting point) for the growing oligonucleotide chain.
Critically, this nucleoside can be a natural unit or, based on specific drug requirements, a modified monomer pre-functionalized with groups like amines, fluorophores, or cholesterol. This versatility ensures efficient and accurate construction of custom sequences.
Applications in Nucleic Acid Therapeutics
Poresyn Solutions’ Modified is crucial for synthesizing various sequences, primarily supporting the industrial production of (Antisense Oligonucleotide) and (small interfering ) drugs. Specifically, it is utilized for:
Drugs: Used to construct the sequence, especially for those requiring custom modifications at the terminus to enhance stability and biological activity.
Drug Components: It serves as the starting support for synthesizing components within duplexes, such as the overhangs (wings) or the antisense strand itself.
Synthesis: The support is also applicable for synthesizing long nucleic acid sequences, such as the templates required for the production of -related guide ().
What is the pore size range of your hybrid solid support?
The pore size range of our hl-cpg (co-polymer coated cpg solid support) is 500A, 1000A, 2000A, and 3000A.
Do you offer custom pore sizes for customer applications?
yes, depends on customer’s specific request, we can provide custom pore size, like 550A, 1400A, 1700A, etc.
Can your HL-CPG synthesize long-chain gRNA, such as those over 100 nt?
Yes, our HyperLink CPG solid support is primarily designed for long-chain oligonucleotide synthesis, and it performs excellently for oligos up to 300 nt.
Can your co-polymer coated CPG be integrated with a cell delivery system?
Actually, we can install cell delivery much more easily and effectively than with equivalent functionalized CPG because the ps layer is covered with the core structure of controlled pore glass.
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detracto
Related Product
Custom modifications of our co-polymer coated controlled pore glass, such as DNA/RNA modified HL-CPG, 2′-O-Methyl modified, reverse functionalized, LNA modified, 2′-F modified, and others, are typically available upon request.
RNA Modified CPG Co-Polymer
2'-O-Methyl Modified CPG Co-Polymer
Reverse Functionalized CPG Co-Polymer
LNA Modified CPG Co-Polymer
2'-F Modified CPG Co-Polymer
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Test the power of our Super Solid Support.
Would you like to test our next-generation co-polymer coated CPG? Get in touch with us right now; we offer a free sample of our HL-CPG with unylinker for rapid testing.