Co-Polymer Coated Universal CPG Solid Support
3-6x loading capacity than traditional CPG and over 80% UV Purity to lower down the downstream purification cost
UnyLinker™ CPG, with DMT on (N-Ph)
Our co-polymer UnyLinker CPG, with its unique architecture combining polystyrene resin and CPG, delivers unmatched performance in oligonucleotide synthesis.
- 3–6× higher loading capacity compared to traditional UnyLinker CPGs
- Inert to chemical reagents and solvents during DNA or RNA synthesis and subsequent treatments
- No swelling under reaction conditions
- Structural stability: pore size and overall structure remain stable, preventing CPG damage during modifications or synthesis reactions
Our Standard CPG(Co-Polymer) Pore Size Range
We offer a wide range of Co-Polymer Coated CPG (Controlled Pore Glass) solid supports with various pore sizes, from 500 to 3000 Angstrom . This selection allows us to meet the synthesis requirements for oligonucleotide chain lengths of up to 200 nucleotides (nt).
Why we offer 300%+ output than traditional CPG
Traditional CPG supports can synthesize long chains, but their structure typically limits them to a low loading capacity. Our patented PS+CPG technology delivers a solution, boosting the loading capacity by 3 to 6 times. The PS coating gives us the benefit of polystyrene’s high loading capacity and its high reaction activity, which means we don’t have to rely on additional molecular structures to achieve excellent chemical reactivity.
Why we achieve 80%+ purity of nucleic acid
Traditional CPG suffers from chemical and solvent corrosion, structural damage during modification that causes CPG fragmentation, and poor chemical activity, which all limit nucleic acid purity to about .
In contrast, our co-polymer coated CPG achieves or greater purity thanks to several advantages:
The resin coating protects the support from chemical and solvent corrosion.
Its stable structure prevents damage, ensuring no CPG fragments are generated.
The highly active resin surface dramatically increases synthesis efficiency compared to traditional CPG.
Advantages of Our Hybird CPG Solid Support
Poresyn Solutions’ new architecture co-polymer coated CPG is combining polystyrene resin and traditional controlled pore glass solid support, by applying the thin resin coating onto surface of CPG, we get excellent performance with loading capacity and purity and long-chain oligonucleotide synthesis capability.
Main advantages of our hybrid CPG solid support:
- High load capacity: 2-3x loading capacity than traditional CPG solid support.
- Anti-corrosion: iner to chemical reagents and solvents during synthesis and subsequents treatments.
- Non-swelling properties: preventing the swelling of resin during chemical reaction.
- Long-chain bases synthesis: supporting medium to extra long chain bases synthesis.
How We Guarantee GMP Compliance in Synthesis Operations.
We apply a high-quality CPG core with a stable, ultra-thin layer of PS (polystyrene) coating. This thin layer is crucial because it will not swell during chemical reactions or under high heat. This eliminates the risk of facility damage or explosions, ensuring manufacturing safety.
Furthermore, the highly stable structure of our coated CPG prevents damage and the generation of fragments before or after synthesis. This guarantees that your synthesizer pipelines won’t clog, removing the need for strong force to maintain smooth flow and preventing high back pressure. The result is a secure and highly reliable production process.
Revolutionizing Industrial Scale-Up for Long Oligonucleotide Synthesis
Our patented technology is specifically designed to solve the challenge of scale-up production for long-chain oligonucleotides (e.g., ). Traditional CPG is limited by low output efficiency and low loading capacity, which restricts industrial-scale manufacturing. By providing a product with both high loading capacity and high purity, we significantly boost the production efficiency for these critical long oligos.
Wha'ts Unylinker CPG with co-polymer coated
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Advantage of using Universe CPG solid support
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