High-Loading Co-polymer Coated CPG & Phosphoramidites for Precision Oligo Synthesis
Poresyn Technologies supplies CPG solid supports and all-series phosphoramidites required for oligonucleotide production.
Introduction
PORESYN TECHNOLOGIES is a premier global supplier of raw materials for nucleic acid synthesis. We specialize in the R&D and production of high-performance co-polymer coated CPG (Controlled Pore Glass) solid supports and ultra-high-purity phosphoramidites.
By delivering exceptional loading capacity and superior physical stability, our products are widely utilized in:
Long-chain sgRNA production
Nucleic acid drug development
We are committed to empowering the life sciences industry with the foundational materials required for the next generation of genomic innovation.
Why Choose PORESYN?
We are a premier oligonucleotide synthesis integrator, providing a One-Stop Solution to simplify complex synthesis workflows for biotech partners.
Proprietary PS-CPG Crosslinked Technology Our unique hybrid architecture delivers High Loading and Extreme Stability, ensuring superior purity levels and seamless adaptability to custom linkers.
Full-Spectrum Material Platform Beyond solid supports, we provide a complete series of high-purity monomers, including GalNAc delivery systems, P-reagents, ribose series, and nucleoside analogues.
Our Goal: To serve as your total integration partner, offering the most streamlined and efficient synthesis solutions from start to finish.
Technical Specifications: Industry-Leading Loading Performance
PORESYN’s co-polymer coated CPG features advanced surface modification. By maintaining high coupling efficiency while delivering loading capacities far exceeding industry standards, we empower large-scale industrial production.
| Pore Size | Loading Capacity | Core Benefits |
|---|---|---|
| 500 Å | 200 - 240 μmol/g | Ultra-High Loading: Designed for high-throughput short primers; doubles yield per run. |
| 1000 Å | 100 - 150 μmol/g | Optimal Balance: Minimized steric hindrance with high yield; ideal for DNA/RNA & ASO. |
| 2000 Å | 40 - 80 μmol/g | Long-Chain Specialist: Optimized for sgRNA, gRNA, and complex secondary structures. |
Your Complete Supply Chain for Oligo Synthesis
At Poresyn Technologies, we operate as a seamlessly integrated manufacturer and global supplier. While we take immense pride in the in-house R&D and production of our proprietary Co-Polymer Coated CPG, our capabilities extend far beyond solid supports.
We understand that large-scale oligonucleotide manufacturing relies on a diverse ecosystem of high-purity chemicals. To streamline your procurement, we have built a fully integrated raw material platform.
Premium Phosphoramidites
High-fidelity DNA/RNA monomers and advanced nucleoside analogues optimized for minimal side reactions during coupling.
Synthesis Reagents
Complete suite of activators, deblocking solutions, oxidizers, and capping reagents precisely formulated for automated synthesis platforms.
Specialty Modifiers
Innovative GalNAc delivery systems, custom linkers, and fluorescent dyes to empower your next-generation targeted therapeutics.
Universal Compatibility: Pre-packed Columns for Every Platform
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- MerMade (6, 12, 192)
- Dr. Oligo Series
- Biolytic Instruments
- ABI 3900 / 394
- AKTA OligoPilot
- Luer-Slip / Syringe Type
Optimized flow-rates and leak-free solutions tailored to your instrument.
Your One-Stop Hub For Oligonucleotide Synthesis
By combining our proprietary solid support manufacturing with a robust chemical supply chain, we act as your true “One-Stop Hub.” Consolidate your sourcing, reduce supply chain friction, and secure all your foundational materials from a single, reliable partner.
Product Catalogue
| Category | Sub-Category | Product Name | Base/Modifier | Protection Group | Form | Comment/Pore Size |
|---|---|---|---|---|---|---|
| Synthesis Columns | DNA Columns | 5'-DMT-dA (Bz)-Suc-co-polymer coated CPG Column | dA | Benzoyl (Bz) | Pre-packed Column | 500Å/1000Å/2000Å |
| Synthesis Columns | DNA Columns | 5'-DMT-dC (Bz)-Suc-co-polymer coated CPG Column | dC | Benzoyl (Bz) | Pre-packed Column | 500Å/1000Å/2000Å |
| Synthesis Columns | DNA Columns | dA (Bz) co-polymer coated CPG Column | dA | Benzoyl (Bz) | Pre-packed Column | 500Å/1000Å/2000Å |
| Synthesis Columns | DNA Columns | dA (Pac) co-polymer coated CPG Column | dA | Phenoxyacetyl (Pac) | Pre-packed Column | 500Å/1000Å/2000Å |
| Synthesis Columns | DNA Columns | dC (Ac) CNA co-polymer coated CPG Column | dC | Acetyl (Ac) | Pre-packed Column | 500Å/1000Å/2000Å |
| Synthesis Columns | DNA Columns | dC (Ac) CNA co-polymer coated CPG (Low Bulk Density) | dC | Acetyl (Ac) | Pre-packed Column | Low Bulk Density Opt. |
| Bulk CPG | DNA Support | dG (dmf) CNA co-polymer coated CPG | dG | dimethylformamidine (dmf) | Bulk Media | 500Å/1000Å/2000Å |
| Bulk CPG | DNA Support | dG (dmf) CNA co-polymer coated CPG (Low Bulk Density) | dG | dimethylformamidine (dmf) | Bulk Media | Low Bulk Density |
| Bulk CPG | DNA Support | dG (iBu) CNA co-polymer coated CPG | dG | isobutyryl (iBu) | Bulk Media | 500Å/1000Å/2000Å |
| Bulk CPG | DNA Support | dG (iBu) CNA co-polymer coated CPG (Low Bulk Density) | dG | isobutyryl (iBu) | Bulk Media | Low Bulk Density |
| Bulk CPG | DNA Support | dT CNA co-polymer coated CPG | dT | None | Bulk Media | 500Å/1000Å/2000Å |
| Bulk CPG | RNA Support | rA (Ac), 2'-OAc CNA co-polymer coated CPG | rA | Acetyl (Ac) | Bulk Media | 2000Å Optimized |
| Bulk CPG | RNA Support | rA (Bz) AMP co-polymer coated CPG | rA | Benzoyl (Bz) | Bulk Media | High Stability |
| Bulk CPG | RNA Support | rA (Bz) CNA co-polymer coated CPG | rA | Benzoyl (Bz) | Bulk Media | 500Å/1000Å/2000Å |
| Bulk CPG | RNA Support | rA (Bz) CNA co-polymer coated CPG (Low Bulk Density) | rA | Benzoyl (Bz) | Bulk Media | Low Bulk Density |
| Bulk CPG | RNA Support | rA (Bz), 2'-OAc CNA (N16) co-polymer coated CPG | rA | Benzoyl (Bz) | Bulk Media | Long Chain Opt. |
| Bulk CPG | RNA Support | rA (Pac) CNA co-polymer coated CPG | rA | Phenoxyacetyl (Pac) | Bulk Media | 500Å/1000Å/2000Å |
| Monomers | DNA Phosphoramidite | U CE-Phosphoramidite | U | Standard | Powder | >99.5% Purity |
| Monomers | DNA Phosphoramidite | dT CE-Phosphoramidite | dT | Standard | Powder | >99.5% Purity |
| Monomers | DNA Phosphoramidite | dA (Bz) CE-Phosphoramidite | dA | Benzoyl (Bz) | Powder | Standard Grade |
| Monomers | DNA Phosphoramidite | dA (Pac) CE-Phosphoramidite | dA | Phenoxyacetyl (Pac) | Powder | Fast Deprotection |
| Monomers | DNA Phosphoramidite | dC (Ac) CE-Phosphoramidite | dC | Acetyl (Ac) | Powder | Fast Deprotection |
| Monomers | DNA Phosphoramidite | dC (Bz) CE-Phosphoramidite | dC | Benzoyl (Bz) | Powder | Standard Grade |
| Monomers | DNA Phosphoramidite | dG (dmf) CE-Phosphoramidite | dG | dimethylformamidine (dmf) | Powder | High Efficiency |
| Monomers | DNA Phosphoramidite | dG (iBu) CE-Phosphoramidite | dG | isobutyryl (iBu) | Powder | Standard Grade |
| Monomers | DNA Phosphoramidite | dG (iPr-Pac) CE-Phosphoramidite | dG | iPr-Pac | Powder | Ultra Fast |
| Monomers | RNA Phosphoramidite | rA (Bz) CE-Phosphoramidite | rA | Benzoyl (Bz) | Powder | RNA Grade |
| Monomers | RNA Phosphoramidite | rC (Ac) CE-Phosphoramidite | rC | Acetyl (Ac) | Powder | RNA Grade |
This technical data sheet highlights a selection of PORESYN TECHNOLOGIES’ high-performance materials for oligonucleotide synthesis. The following catalog features our key offerings, including our signature co-polymer coated CPG (500Å to 2000Å) with industry-leading loading capacities, specialized pre-packed synthesis columns for MerMade, Syringe, and Luer platforms, and high-purity nucleoside phosphoramidites. Please note that this list represents only a part of our extensive portfolio; we offer a wider range of custom loading, modified supports, and bulk solutions tailored to your specific research and industrial requirements.
How does your Co-Polymer Coated CPG prevent "bed shrinking" in large-scale columns?
Unlike traditional native glass, our proprietary co-polymer coating creates a cross-linked organic-inorganic hybrid matrix. This architecture provides superior mechanical strength that resists compression and swelling even under high-pressure flow in large-scale columns (e.g., AKTA OligoPilot). This ensures consistent bed height and stable pressure profiles throughout the entire synthesis cycle.
What is the typical coupling efficiency when synthesizing 200+ nt sequences using your 2000Å CPG?
Our 2000Å long-chain specialist CPG is optimized to minimize steric hindrance. In internal benchmarks, we consistently achieve an average stepwise coupling efficiency of >99% for sequences up to 200–300 nt. This high efficiency significantly reduces truncation products (n-1), making the final PAGE/HPLC purification of ultra-long oligos much more efficient.
Can your pre-packed columns be customized for specialized synthesizers like Dr. Oligo or custom-built platforms?
Yes. We offer a “Hardware Integration” service. Beyond standard MerMade and ABI-style columns, we can provide custom-filled fritted columns or Luer-locking hardware designed for specific flow dynamics. We also provide bulk CPG with customized loading (µmol/g) to match your internal SOPs for specific molar equivalents.
How do you ensure batch-to-batch consistency for GMP-grade raw materials?
Poresyn operates under an ISO 9001:2015 quality system. For every batch of CPG and phosphoramidites, we provide a comprehensive Certificate of Analysis (CoA). Our CPG is tested for pore size distribution (BET), loading precision, and functional synthesis performance. For phosphoramidites, we guarantee >99.5% purity via 31P-NMR and HPLC, with strictly controlled moisture content (<100 ppm).
Are your reagents compatible with fast-deprotection chemistries (e.g., AMA or ultra-mild conditions)?
Absolutely. Our full-spectrum material platform includes monomers and CPG linkers compatible with standard (Benzoyl/Isobutyryl), fast (Ac/dmf), and ultra-mild (Pac) deprotection strategies. This allows you to synthesize complex or sensitive oligos (like those with certain fluorescent dyes) without degrading the product during cleavage.
Do you provide support for regulatory filings (DMF/CMC)?
As a dedicated industry partner, we understand the regulatory requirements for moving from R&D to clinical trials. We can provide technical data packages and support documentation necessary for your DMF (Drug Master File) or CMC (Chemistry, Manufacturing, and Controls) sections to facilitate a smoother IND/NDA submission process.
Which synthesizer platforms are your pre-packed columns compatible with?
We offer a versatile range of pre-packed hardware designed for 100% compatibility with industry-standard synthesizers. This includes:
High-Throughput Platforms: MerMade (6, 12, 192), ABI 3900, and Dr. Oligo series.
Process Development Platforms: AKTA OligoPilot and Biolytic instruments.
Manual Synthesis: Standard Luer-Slip and Syringe-style columns for small-scale R&D. All columns are precision-filled with our proprietary CPG to ensure optimized flow rates and zero leakage.
Do you offer custom oligonucleotide synthesis services, and what are your specialties?
Yes, Poresyn provides high-end custom synthesis services. Our core advantage lies in Long and Complex Oligonucleotide Synthesis (100–300+ nt). By utilizing our proprietary Hyper-Link CPG technology, we overcome the common fidelity issues found in traditional synthesis, delivering ultra-long sequences with superior purity for CRISPR gRNA, gene assembly, and antisense research.
Can I request custom linkers or specialized monomers to be conjugated to your Hyper-Link CPG?
Absolutely. We provide a Highly Customizable Matrix. Whether you require specific 5’, 3’, or internal modifications, or you need your own proprietary monomers/linkers loaded onto our high-performance CPG, our technical team can handle the conjugation. We ensure the loading capacity (µmol/g) is precisely calibrated to match your specific synthesis protocol.
In what formats are your products delivered, and how do you ensure stability during transit?
We offer flexible delivery formats, including lyophilized powders, bulk media, and stabilized liquid forms. To guarantee maximum stability:
CPG Powders: Packaged in amber glass vials, vacuum-sealed, and backfilled with high-purity Nitrogen (N2) to prevent oxidation.
Large-Scale Orders: Shipped via Cold-Chain Logistics when necessary to maintain chemical integrity.
Documentation: Every shipment includes a detailed CoA and optimized storage guidelines to ensure the longevity of your raw materials.